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The clinical use of platelet scintigraphy with 111-In-oxine

Identifieur interne : 000740 ( Main/Exploration ); précédent : 000739; suivant : 000741

The clinical use of platelet scintigraphy with 111-In-oxine

Auteurs : RBID : ISTEX:415_1983_Article_BF00313554.pdf

English descriptors

Abstract

Platelet scintigraphy was performed on 62 patients with cerebral ischaemia. Pathological scintigraphic images were obtained in 29 of the 62 patients. In 79.3% of these 29 patients the scan was abnormal in the vessel clinically affected. Platelet scintigraphy was abnormal in 21 of 34 patients with normal angiogram or only slight atherosclerosis. In patients undergoing antiplatelet therapy, platelet scintigraphy was less often positive than in untreated patients. It is suggested that platelet scintigraphy could be an appropriate technique for detecting small mural thrombi of the carotid artery, which are the source of arterio-arterial emboli, and for controlling the efficiency of antiplatelet therapy.

DOI: 10.1007/BF00313554

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Le document en format XML

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<name>Ch. Kessler</name>
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<mods:affiliation>Department of Neurology, Ruprecht-Karls University, D-6900, Heidelberg, Federal Republic of Germany</mods:affiliation>
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<name>R. Reuther</name>
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<name>J. Berentelg</name>
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<name>B. Kimmig</name>
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<div type="abstract" xml:lang="eng">Platelet scintigraphy was performed on 62 patients with cerebral ischaemia. Pathological scintigraphic images were obtained in 29 of the 62 patients. In 79.3% of these 29 patients the scan was abnormal in the vessel clinically affected. Platelet scintigraphy was abnormal in 21 of 34 patients with normal angiogram or only slight atherosclerosis. In patients undergoing antiplatelet therapy, platelet scintigraphy was less often positive than in untreated patients. It is suggested that platelet scintigraphy could be an appropriate technique for detecting small mural thrombi of the carotid artery, which are the source of arterio-arterial emboli, and for controlling the efficiency of antiplatelet therapy.</div>
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<abstract lang="eng">Platelet scintigraphy was performed on 62 patients with cerebral ischaemia. Pathological scintigraphic images were obtained in 29 of the 62 patients. In 79.3% of these 29 patients the scan was abnormal in the vessel clinically affected. Platelet scintigraphy was abnormal in 21 of 34 patients with normal angiogram or only slight atherosclerosis. In patients undergoing antiplatelet therapy, platelet scintigraphy was less often positive than in untreated patients. It is suggested that platelet scintigraphy could be an appropriate technique for detecting small mural thrombi of the carotid artery, which are the source of arterio-arterial emboli, and for controlling the efficiency of antiplatelet therapy.</abstract>
<abstract lang="ger">Bei 62 Patienten mit zerebralen Ischämien wurde ein Plättchenszintigramm durchgeführt. Dieses war in 29 der 62 Fälle pathologisch. Die pathologischen Aktivitätsanreicherungen zeigten sich in 79.3% der 29 Fälle im klinisch betroffenen Gefäßgebiet. In 34 Fällen zeigte das Angiogramm nur leichte arteriosklerotische Gefäßwandunregelmäßigkeiten oder war unauffällig, trotzdem war das Plättchenszintigramm 21mal positiv. Nach Behandlung mit Plättchenaggregationshemmern war das Plättchenszintigramm seltener positiv als bei unbehandelten Patienten. Das Plättchenszintigramm kann die geeignete Methode sein, um sowohl flache wandständige Thromben der A. carotis nachzuweisen, als auch zur Effizienzkontrolle der Therapie mit Plättchenaggregationshemmern verwendet werden.</abstract>
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<title>J Neurol</title>
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